The Hypoglycemic Effect of Some Medicinal Plants in Normal and Experimentally Induced Diabetic Rabbits

38 Abstract Alloxan (180mg/Kg] I.V is an effective diabetogenic agent that induces diabetes mellitus in rabbits. Ninety healthy male rabbits were involved in this study. The plasma glucose levels were measured in normal and in diabetic rabbits after giving alloxan and following the administration of glibenclamide, insulin and the aqueous extract of medicinal plants. Insulin (2IU/Kg] S.C produced a significant reduction in plasma glucose levels in diabetic rabbits (b= -3.87 P< 0.001]. In the mean time, the aqueous extract of Cinnamomum verum, Nigella sativa and Olea europea at a single dose of 0.5g/Kg orally caused a significant lowering of plasma glucose levels in diabetic rabbits with b=(-2.38], (-2.34 ] and (-1.17] respectively (P< 0.05], whereas the aqueous extract of both Capparis spinos and Coriandum sativum at the same dose produced non significant decrease in plasma glucose levels of diabetic rabbits with b= (-0.86] and (-0.98] respectively (P> 0.05]. The aqueous extract of medicinal plants significantly decreased the plasma glucose levels in normal rabbits except with Capparis spinos, whereas glibenclamide insignificantly reduced the plasma glucose levels in diabetic rabbits. ةصلاخلا ناسكوللاا ربتعي ) 180 مغام / مغك ( بنارلأا يف ركسلا ءاد ثادحلإ ةلاعف ةدام ديرولاب قرزلاب . ةميلسلا بنارلأا روكذ نم نوعست ةساردلا هذه تلمش . بـنارلأاو ةميلسـلا بـنارلأل امزلابلا يف ركسلا ىوتسم سايق متو نبلكلا ءاطعإ دعب كلذكو ايبيرجت ركسلا اهيف ثدحملا ةيبطلا تاتابنلل يئاملا صلختسملاو نيلوسنلااو دياملك . ةعرجب نيلوسنلاا ءاطعإ جتن ) 2 ةيلود ةدحو / مغك ( بـنارلأل اـمزلابلا يف ركسلا ىوتسم يف يونعم ضافخنا دلجلا تحت ركسلا ءادب ةباصملا ) b=-3.87, P < 0.001 ( . او نيسرادلل يئاملا صلختسملا نم ةدرفم ةعرج ناف تقولا سفن يفو ءادوسـلا ةـبحل اهرادقم نوتيزلاو 0,5 مغ / ركسـلا ءادب ةباصملا بنارلأل امزلابلا يف ركسلا ىوتسم يف يونعم ناصقن تببس مفلاب مغك ) -2.38]b=(-